Bone-marrow Stromal Cells Exert Immunosuppressive Effects on Immune Cells Co-cultivated in 3D Alginate Scaffolds

Yael Kaminer; Smadar Cohen; Alan Monsonego

doi:10.1016/j.clim.2009.03.336

Bone-marrow Stromal Cells Exert Immunosuppressive Effects on Immune Cells Co-cultivated in 3D Alginate Scaffolds

Yael Kaminer, Smadar Cohen, Alan Monsonego

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Stromal cells have been shown to exert a potent immunosuppressive effect on immune cells when co-cultivated on flat two-dimensional (2D) dishes1 . Yet, 2D cell cultivation may not reliably represent cell function in a physiological setting.
In this work we investigated whether stromal cells would exert immunosuppression on bone marrow derived dendritic cells (BMDC) and T cells, when co-cultured within 3D porous alginate scaffolds2 . Alginate scaffolds herein are replacing the extracellular matrix (ECM), providing both a physical support and biological
cues for the seeded cells and closing the gap to in vivo conditions.

Original language	English
Pages (from-to)	S114-S114
Journal	Clinical Immunology
Volume	131
DOIs	https://doi.org/10.1016/j.clim.2009.03.336
State	Published - Apr 2009

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title = "Bone-marrow Stromal Cells Exert Immunosuppressive Effects on Immune Cells Co-cultivated in 3D Alginate Scaffolds",

abstract = "Stromal cells have been shown to exert a potent immunosuppressive effect on immune cells when co-cultivated on flat two-dimensional (2D) dishes1 . Yet, 2D cell cultivation may not reliably represent cell function in a physiological setting.In this work we investigated whether stromal cells would exert immunosuppression on bone marrow derived dendritic cells (BMDC) and T cells, when co-cultured within 3D porous alginate scaffolds2 . Alginate scaffolds herein are replacing the extracellular matrix (ECM), providing both a physical support and biologicalcues for the seeded cells and closing the gap to in vivo conditions.",

author = "Yael Kaminer and Smadar Cohen and Alan Monsonego",

year = "2009",

month = apr,

doi = "10.1016/j.clim.2009.03.336",

language = "English",

volume = "131",

pages = "S114--S114",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Bone-marrow Stromal Cells Exert Immunosuppressive Effects on Immune Cells Co-cultivated in 3D Alginate Scaffolds

AU - Kaminer, Yael

AU - Cohen, Smadar

AU - Monsonego, Alan

PY - 2009/4

Y1 - 2009/4

N2 - Stromal cells have been shown to exert a potent immunosuppressive effect on immune cells when co-cultivated on flat two-dimensional (2D) dishes1 . Yet, 2D cell cultivation may not reliably represent cell function in a physiological setting.In this work we investigated whether stromal cells would exert immunosuppression on bone marrow derived dendritic cells (BMDC) and T cells, when co-cultured within 3D porous alginate scaffolds2 . Alginate scaffolds herein are replacing the extracellular matrix (ECM), providing both a physical support and biologicalcues for the seeded cells and closing the gap to in vivo conditions.

AB - Stromal cells have been shown to exert a potent immunosuppressive effect on immune cells when co-cultivated on flat two-dimensional (2D) dishes1 . Yet, 2D cell cultivation may not reliably represent cell function in a physiological setting.In this work we investigated whether stromal cells would exert immunosuppression on bone marrow derived dendritic cells (BMDC) and T cells, when co-cultured within 3D porous alginate scaffolds2 . Alginate scaffolds herein are replacing the extracellular matrix (ECM), providing both a physical support and biologicalcues for the seeded cells and closing the gap to in vivo conditions.

U2 - 10.1016/j.clim.2009.03.336

DO - 10.1016/j.clim.2009.03.336

M3 - Meeting Abstract

SN - 1521-6616

VL - 131

SP - S114-S114

JO - Clinical Immunology

JF - Clinical Immunology

ER -

Bone-marrow Stromal Cells Exert Immunosuppressive Effects on Immune Cells Co-cultivated in 3D Alginate Scaffolds

Abstract

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