Boolean logic functions of a synthetic peptide network

Gonen Ashkenasy, M. Reza Ghadiri

Research output: Contribution to journalArticlepeer-review

207 Scopus citations


Living cells can process rapidly and simultaneously multiple extracellular input signals through the complex networks of evolutionary selected biomolecular interactions and chemical transformations. Recent approaches to molecular computation have increasingly sought to mimic or exploit various aspects of biology. A number of studies have adapted nucleic acids and proteins to the design of molecular logic gates and computational systems, while other works have affected computation in living cells via biochemical pathway engineering. Here we report that de novo designed synthetic peptide networks can also mimic some of the basic logic functions of the more complex biological networks. We show that segments of a small network whose graph structure is composed of five nodes and 15 directed edges can express OR, NOR, and NOTIF logic.

Original languageEnglish
Pages (from-to)11140-11141
Number of pages2
JournalJournal of the American Chemical Society
Issue number36
StatePublished - 15 Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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