Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides

Raju Sharma; Gowtham Kenguva; Rambabu Dandela; Prosenjit Daw

doi:10.1039/d5cc00399g

Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides

Raju Sharma
, Gowtham Kenguva
, Rambabu Dandela
, Prosenjit Daw

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.

Original language	English
Pages (from-to)	9460-9463
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	52
DOIs	https://doi.org/10.1039/d5cc00399g
State	Published - 15 May 2025
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d5cc00399g

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title = "Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides",

abstract = "Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.",

author = "Raju Sharma and Gowtham Kenguva and Rambabu Dandela and Prosenjit Daw",

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T1 - Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides

AU - Sharma, Raju

AU - Kenguva, Gowtham

AU - Dandela, Rambabu

AU - Daw, Prosenjit

PY - 2025/5/15

Y1 - 2025/5/15

N2 - Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.

AB - Herein, we disclosed a selective hydrogenation of tertiary amides and desulfurization of thioamides to amines with phenylsilane as a reductant, using a bifunctional Ru-NHC complex 1 appended with a Lewis acid in the secondary coordination sphere. The catalytic process was further utilized to synthesize biologically relevant amine drug molecules in good yields.

UR - https://www.scopus.com/pages/publications/105007048303

U2 - 10.1039/d5cc00399g

DO - 10.1039/d5cc00399g

M3 - Article

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AN - SCOPUS:105007048303

SN - 1359-7345

VL - 61

SP - 9460

EP - 9463

JO - Chemical Communications

JF - Chemical Communications

IS - 52

ER -

Boron appended Ru-NHC catalyzed selective deoxygenative hydrogenation of tertiary amides and desulfurization of thioamides

Abstract

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