Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Hang Xing; Yugang Bai; Yunhao Bai; Li Huey Tan; Jing Tao; Benjamin Pedretti; Gretchen A. Vincil; Yi Lu; Steven C. Zimmerman

doi:10.1021/jacs.7b00065

Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Hang Xing, Yugang Bai, Yunhao Bai, Li Huey Tan, Jing Tao, Benjamin Pedretti, Gretchen A. Vincil, Yi Lu, Steven C. Zimmerman

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.

Original language	English
Pages (from-to)	3623-3626
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	139
Issue number	10
DOIs	https://doi.org/10.1021/jacs.7b00065
State	Published - 15 Mar 2017
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry (all)
Biochemistry
Colloid and Surface Chemistry

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title = "Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand",

abstract = "We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.",

author = "Hang Xing and Yugang Bai and Yunhao Bai and Tan, {Li Huey} and Jing Tao and Benjamin Pedretti and Vincil, {Gretchen A.} and Yi Lu and Zimmerman, {Steven C.}",

note = "Funding Information: This work was supported by the National Science Foundation (CHE-1307404 and CTS-0120978), the Binational Science Foundation (2014116), the National Institutes of Health (MH110975). Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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AU - Xing, Hang

AU - Bai, Yugang

AU - Bai, Yunhao

AU - Tan, Li Huey

AU - Tao, Jing

AU - Pedretti, Benjamin

AU - Vincil, Gretchen A.

AU - Lu, Yi

AU - Zimmerman, Steven C.

N1 - Funding Information: This work was supported by the National Science Foundation (CHE-1307404 and CTS-0120978), the Binational Science Foundation (2014116), the National Institutes of Health (MH110975). Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/3/15

Y1 - 2017/3/15

N2 - We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.

AB - We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.

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Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Abstract

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