Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Hang Xing, Yugang Bai, Yunhao Bai, Li Huey Tan, Jing Tao, Benjamin Pedretti, Gretchen A. Vincil, Yi Lu, Steven C. Zimmerman

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.

Original languageEnglish
Pages (from-to)3623-3626
Number of pages4
JournalJournal of the American Chemical Society
Issue number10
StatePublished - 15 Mar 2017
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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