TY - JOUR
T1 - Brain functional networks reorganization for maintaining gait abilities in aging
AU - Droby, Amgad
AU - Maidan, Inbal
AU - Mirelman, Anat
N1 - Publisher Copyright:
© 2023 Droby et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Neural changes occurring at the molecular and functional levels in the brain as a function of age were reported by numerous studies. These age-related alterations manifest as local structural and metabolic changes and large-scale functional re-organization of neural circuits, and are accompanied by a decline in multiple cognitive and motor skills [1, 2]. However, the aging process is heterogeneous, varying extensively between individuals. A potential explanation for this variance relates to the concepts of brain reserve, cognitive reserve, and their contribution to brain resilience. Brain resilience is a broad term increasingly used to refer to [one’s] capacity to withstand and maintain functions in the face of aging or disease. Brain reserve (BR) is proposed to be one aspect of brain resilience, offering a quantifiable measure of the neurobiological characteristics of the underlying neural tissue (i.e., neuronal density, tissue volumes, etc.),
AB - Neural changes occurring at the molecular and functional levels in the brain as a function of age were reported by numerous studies. These age-related alterations manifest as local structural and metabolic changes and large-scale functional re-organization of neural circuits, and are accompanied by a decline in multiple cognitive and motor skills [1, 2]. However, the aging process is heterogeneous, varying extensively between individuals. A potential explanation for this variance relates to the concepts of brain reserve, cognitive reserve, and their contribution to brain resilience. Brain resilience is a broad term increasingly used to refer to [one’s] capacity to withstand and maintain functions in the face of aging or disease. Brain reserve (BR) is proposed to be one aspect of brain resilience, offering a quantifiable measure of the neurobiological characteristics of the underlying neural tissue (i.e., neuronal density, tissue volumes, etc.),
KW - aging
KW - brain reserve
KW - brain resilience
KW - functional integration
KW - gait
UR - http://www.scopus.com/inward/record.url?scp=85150751075&partnerID=8YFLogxK
U2 - 10.18632/aging.204556
DO - 10.18632/aging.204556
M3 - Editorial
C2 - 36881387
AN - SCOPUS:85150751075
SN - 1945-4589
VL - 15
SP - 1230
EP - 1231
JO - Aging
JF - Aging
IS - 5
ER -