Brain metabolic effects of acute nicotine

Jay W. Pettegrew, Kanagasabai Panchalingam, Richard J. Mcclure, Joseph Levine

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    (-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. 31P NMR analysis reveals subcutaneously administered (-)nicotine produces acute alterations in brain membrane phospholipid and high-energy phosphate metabolism of Fischer 344 rats. These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects.

    Original languageEnglish
    Pages (from-to)181-185
    Number of pages5
    JournalNeurochemical Research
    Issue number2
    StatePublished - 30 Jul 2001


    • Addiction
    • Brain phospholipid metabolism
    • High-energy phosphate metabolism
    • Nicotine
    • P NMR
    • Phospholipids

    ASJC Scopus subject areas

    • Biochemistry
    • Cellular and Molecular Neuroscience


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