Brain metabolic effects of acute nicotine

Jay W. Pettegrew; Kanagasabai Panchalingam; Richard J. Mcclure; Joseph Levine

doi:10.1023/A:1011007131195

Brain metabolic effects of acute nicotine

Jay W. Pettegrew, Kanagasabai Panchalingam, Richard J. Mcclure, Joseph Levine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

(-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. ³¹P NMR analysis reveals subcutaneously administered (-)nicotine produces acute alterations in brain membrane phospholipid and high-energy phosphate metabolism of Fischer 344 rats. These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Neurochemical Research
Volume	26
Issue number	2
DOIs	https://doi.org/10.1023/A:1011007131195
State	Published - 30 Jul 2001

Keywords

Addiction
Brain phospholipid metabolism
High-energy phosphate metabolism
Nicotine
P NMR
Phospholipids

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1023/A:1011007131195

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title = "Brain metabolic effects of acute nicotine",

abstract = "(-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. 31P NMR analysis reveals subcutaneously administered (-)nicotine produces acute alterations in brain membrane phospholipid and high-energy phosphate metabolism of Fischer 344 rats. These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects.",

keywords = "Addiction, Brain phospholipid metabolism, High-energy phosphate metabolism, Nicotine, P NMR, Phospholipids",

author = "Pettegrew, {Jay W.} and Kanagasabai Panchalingam and Mcclure, {Richard J.} and Joseph Levine",

note = "Funding Information: This work was supported in part (JWP) by a grant (AG08974) from the National Institutes of Health. We thank Dennis McKeag for technical assistance.",

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T1 - Brain metabolic effects of acute nicotine

AU - Pettegrew, Jay W.

AU - Panchalingam, Kanagasabai

AU - Mcclure, Richard J.

AU - Levine, Joseph

N1 - Funding Information: This work was supported in part (JWP) by a grant (AG08974) from the National Institutes of Health. We thank Dennis McKeag for technical assistance.

PY - 2001/7/30

Y1 - 2001/7/30

N2 - (-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. 31P NMR analysis reveals subcutaneously administered (-)nicotine produces acute alterations in brain membrane phospholipid and high-energy phosphate metabolism of Fischer 344 rats. These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects.

AB - (-)Nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. The behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. 31P NMR analysis reveals subcutaneously administered (-)nicotine produces acute alterations in brain membrane phospholipid and high-energy phosphate metabolism of Fischer 344 rats. These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects.

KW - Addiction

KW - Brain phospholipid metabolism

KW - High-energy phosphate metabolism

KW - Nicotine

KW - P NMR

KW - Phospholipids

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DO - 10.1023/A:1011007131195

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VL - 26

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EP - 185

JO - Neurochemical Research

JF - Neurochemical Research

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ER -

Brain metabolic effects of acute nicotine

Abstract

Keywords

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