Brain Network Activation (BNA) reveals scopolamine-induced impairment of visual working memory

Amit Reches, Naama Levy-Cooperman, Ilan Laufer, Revital Shani-Hershkovitch, Keren Ziv, Dani Kerem, Noga Gal, Yaki Stern, Guy Cukierman, Myroslava K. Romach, Edward M. Sellers, Amir B. Geva

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The overarching goal of this event-related potential (ERP) study was to examine the effects of scopolamine on the dynamics of brain network activation using a novel ERP network analysis method known as Brain Network Activation (BNA). BNA was used for extracting group-common stimulus-activated network patterns elicited to matching probe stimuli in the context of a delayed matching-to-sample task following placebo and scopolamine treatments administered to healthy participants. The BNA extracted networks revealed the existence of two pathophysiological mechanisms following scopolamine, disconnection, and compensation. Specifically, weaker frontal theta and parietal alpha coupling was accompanied with enhanced fronto-centro-parietal theta activation relative to placebo. In addition, using the characteristic BNA network of each treatment as well as corresponding literature-guided selective subnetworks as combined biomarkers managed to differentiate between individual responses to each of the treatments. Behavioral effects associated with scopolamine included delayed response time and impaired response accuracy. These results indicate that the BNA method is sensitive to the effects of scopolamine on working memory and that it may potentially enable diagnosis and treatment assessment of dysfunctions associated with cholinergic deficiency.

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalJournal of Molecular Neuroscience
Issue number1
StatePublished - 1 Jan 2014


  • Brain Network Activation (BNA)
  • Cholinergic hypothesis
  • Dementia
  • Event-related potentials (ERPs)
  • Scopolamine
  • Working memory (WM)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Brain Network Activation (BNA) reveals scopolamine-induced impairment of visual working memory'. Together they form a unique fingerprint.

Cite this