Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia

P. Tiberin; E. Maor; R. Zaizov; I. J. Cohen; M. Hirsch; T. Yosefovich; J. Ronen; J. Goldstein

doi:10.3171/jns.1984.61.4.0772

Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia

P. Tiberin, E. Maor, R. Zaizov, I. J. Cohen, M. Hirsch, T. Yosefovich, J. Ronen, J. Goldstein

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Abstract

The authors report their experience with an unusual case of intracerebral sarcoma of meningeal cell origin in an 8 1/2 -year-old girl. This tumor occurred 6 1/2 years after cranial irradiation at relatively low dosage (2200 rads) had been delivered to the head in the course of a mutlimodality treatment for acute lymphocytic leukemia. The tumor recurred approximately 10 months after the first surgical intervention. Macroscopic total excision of the recurrent growth followed by whole-brain irradiation (4500 rads) failed to eradicate it completely and local recurrence prompted reoperation 18 months later. This complication of treatment in long-term childhood leukemia survivors is briefly discussed, as well as the pathology of meningeal sarcomas.

Original language	English
Pages (from-to)	772-776
Number of pages	5
Journal	Journal of Neurosurgery
Volume	61
Issue number	4
DOIs	https://doi.org/10.3171/jns.1984.61.4.0772
State	Published - 1 Jan 1984

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.3171/jns.1984.61.4.0772

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title = "Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia",

abstract = "The authors report their experience with an unusual case of intracerebral sarcoma of meningeal cell origin in an 8 1/2 -year-old girl. This tumor occurred 6 1/2 years after cranial irradiation at relatively low dosage (2200 rads) had been delivered to the head in the course of a mutlimodality treatment for acute lymphocytic leukemia. The tumor recurred approximately 10 months after the first surgical intervention. Macroscopic total excision of the recurrent growth followed by whole-brain irradiation (4500 rads) failed to eradicate it completely and local recurrence prompted reoperation 18 months later. This complication of treatment in long-term childhood leukemia survivors is briefly discussed, as well as the pathology of meningeal sarcomas.",

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T1 - Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia

AU - Tiberin, P.

AU - Maor, E.

AU - Zaizov, R.

AU - Cohen, I. J.

AU - Hirsch, M.

AU - Yosefovich, T.

AU - Ronen, J.

AU - Goldstein, J.

PY - 1984/1/1

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N2 - The authors report their experience with an unusual case of intracerebral sarcoma of meningeal cell origin in an 8 1/2 -year-old girl. This tumor occurred 6 1/2 years after cranial irradiation at relatively low dosage (2200 rads) had been delivered to the head in the course of a mutlimodality treatment for acute lymphocytic leukemia. The tumor recurred approximately 10 months after the first surgical intervention. Macroscopic total excision of the recurrent growth followed by whole-brain irradiation (4500 rads) failed to eradicate it completely and local recurrence prompted reoperation 18 months later. This complication of treatment in long-term childhood leukemia survivors is briefly discussed, as well as the pathology of meningeal sarcomas.

AB - The authors report their experience with an unusual case of intracerebral sarcoma of meningeal cell origin in an 8 1/2 -year-old girl. This tumor occurred 6 1/2 years after cranial irradiation at relatively low dosage (2200 rads) had been delivered to the head in the course of a mutlimodality treatment for acute lymphocytic leukemia. The tumor recurred approximately 10 months after the first surgical intervention. Macroscopic total excision of the recurrent growth followed by whole-brain irradiation (4500 rads) failed to eradicate it completely and local recurrence prompted reoperation 18 months later. This complication of treatment in long-term childhood leukemia survivors is briefly discussed, as well as the pathology of meningeal sarcomas.

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Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia

Abstract

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