Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia

P. Tiberin, E. Maor, R. Zaizov, I. J. Cohen, M. Hirsch, T. Yosefovich, J. Ronen, J. Goldstein

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39 Scopus citations

Abstract

The authors report their experience with an unusual case of intracerebral sarcoma of meningeal cell origin in an 8 1/2 -year-old girl. This tumor occurred 6 1/2 years after cranial irradiation at relatively low dosage (2200 rads) had been delivered to the head in the course of a mutlimodality treatment for acute lymphocytic leukemia. The tumor recurred approximately 10 months after the first surgical intervention. Macroscopic total excision of the recurrent growth followed by whole-brain irradiation (4500 rads) failed to eradicate it completely and local recurrence prompted reoperation 18 months later. This complication of treatment in long-term childhood leukemia survivors is briefly discussed, as well as the pathology of meningeal sarcomas.

Original languageEnglish
Pages (from-to)772-776
Number of pages5
JournalJournal of Neurosurgery
Volume61
Issue number4
DOIs
StatePublished - 1 Jan 1984

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