Bubble dynamics in double-stranded DNA

Grégoire Altan-Bonnet, Albert Libchaber, Oleg Krichevsky

Research output: Contribution to journalArticlepeer-review

213 Scopus citations


We report the first measurement of the dynamics of bubble formation in double-stranded DNA. Fluctuations of fluorescence of a synthetic DNA construct, internally tagged with a fluorophore and a quencher, are monitored by fluorescence correlation spectroscopy. The relaxation dynamics follow a multistate relaxation kinetics, with a characteristic time scale of 50 microseconds. A simple model of bubble dynamics based on constant zipping-unzipping rates is proposed to account for our experimental data. The role of different secondary structures stabilizing the open bubble is tested.

Original languageEnglish GB
Pages (from-to)138101/1-138101/4
Number of pages4
JournalPhysical Review Letters
Issue number13
StatePublished - 4 Apr 2003

ASJC Scopus subject areas

  • General Physics and Astronomy


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