Abstract
A new method for the synthesis of protected Nα-(ω-Y-alkyl) amino acids (Y is a thio, amino or carboxy group) and related compounds by reductive alkylation of natural amino acids is reported. These new amino acids serve as building units for the synthesis of backbone-cyclic peptides. They are orthogonally protected at the α-amino position by butoxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc), using trimethylsilyl temporary protection, to allow for their incorporation into peptides by solid phase peptide synthesis.
Original language | English |
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Pages (from-to) | 1501-1510 |
Number of pages | 10 |
Journal | Journal of the Chemical Society, Perkin Transactions 1 |
Issue number | 10 |
DOIs | |
State | Published - 21 May 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General Chemistry