Bulk Modification of Carbon Paste Electrode with Bi2O3 Nanoparticles and Its Application as an Electrochemical Sensor for Selective Sensing of Anti-HIV Drug Nevirapine

Nagappa L. Teradal, J. Seetharamappa

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Bi2O3 nanoparticles were synthesized by solution combustion method and utilized for fabrication of an electrochemical sensor [carbon paste electrode modified with Bi2O3 (CPE-Bi2O3)] for nevirapine (NVP). Electrode materials were characterized by XRD, FTIR, TG-DTA, AFM and SEM-EDS methods. CPE-Bi2O3 was electroreduced (Er) in KOH in the potential range of -1.3-0V to obtain CPE-ErBi2O3. CPE-ErBi2O3 exhibited electrocatalytic activity towards the oxidation of NVP. Under optimized conditions, linearity between the peak current and NVP concentration was observed in the range of 0.05-50μM. Further, the sensor was used for the assay of NVP in tablets and biological samples.

Original languageEnglish
Pages (from-to)2007-2016
Number of pages10
JournalElectroanalysis
Volume27
Issue number8
DOIs
StatePublished - 1 Aug 2015
Externally publishedYes

Keywords

  • Analytical applications
  • CPE-ErBiO
  • Electrocatalytic activity
  • Nevirapine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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