C-Met as a new marker of cellular senescence

Maria Boichuck, Jonathan Zorea, Moshe Elkabets, Marina Wolfson, Vadim E. Fraifeld

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Here, we reported for the first time an increased expression of c-Met protein in primary cultures of human dermal and pulmonary fibroblasts of late passages. This suggests that c-Met could serve as an early marker of cellular senescence (CS). The levels of c-Met-related signaling proteins phospho-Akt and Stat3 were also increased in (pre)senescent fibroblasts. Considering the anti-apoptotic activity of Akt and the involvement of Stat3 in mediating the effects of proinflammatory cytokines, the findings of this study indicate that c-Met could contribute through its downstream targets or partners to at least two major phenotypical features of CS - resistance to apoptosis and senescence-associated secretory phenotype.

Original languageEnglish
Pages (from-to)2889-2897
Number of pages9
Issue number9
StatePublished - 15 May 2019


  • Akt
  • C-Met
  • Cellular senescence
  • Human dermal and pulmonary fibroblasts
  • Stat3

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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