CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS

Ayelet David (Inventor), Gonen Ashkenasy (Inventor), Yosi Shamay (Inventor)

Research output: Patent

Abstract

The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.

Original languageEnglish
Patent numberUS2014017169
IPCA61K 49/ 00 A I
Priority date26/05/11
StatePublished - 16 Jan 2014

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