Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?

Roberto Romero, Jimmy Espinoza, Moshe Mazor

Research output: Contribution to journalArticlepeer-review

180 Scopus citations

Abstract

The endometrial cavity is frequently invaded by microorganisms, and subclinical endometrial infection or inflammation may play a role in implantation failure after IVF, spontaneous abortion, and preterm birth. Microbial products and host-inflammatory mediators such as cytokines and chemokines can cause trophoblast apoptosis and the cascade of events leading to expulsion of the embryo or fetus.

Original languageEnglish
Pages (from-to)799-804
Number of pages6
JournalFertility and Sterility
Volume82
Issue number4
DOIs
StatePublished - 1 Jan 2004
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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