Can the Duration of In-Hospital Ventilation in Patients with Sepsis Help Predict Long-Term Survival?

Moti Klein, Adir Israeli, Lior Hassan, Yair Binyamin, Dmitry Frank, Matthew Boyko, Victor Novack, Amit Frenkel

Research output: Contribution to journalArticlepeer-review


Mechanical ventilation is a cornerstone in the treatment of critical illness, especially sepsis. Prolonged mechanical ventilation, for a duration exceeding 21 days, is associated with higher rates of in-hospital and post-discharge mortality. Our aim was to assess the association between in-hospital ventilation duration and long-term life expectancy in patients ventilated in intensive care units specifically due to sepsis of any origin. We conducted a population-based retrospective cohort study of adults hospitalized in a general intensive care unit for 24 h or more during 2007–2017, who were diagnosed with sepsis or septic shock, treated with invasive mechanical ventilation for a maximum of 60 days and survived hospitalization. The primary exposure was the length of invasive mechanical ventilation. In an adjusted multivariable regression model, survival rates at 1, 2, 3 and 4 years post-hospitalization did not differ significantly between patients who were ventilated for 3–8 days (n = 169), 9–21 days (n = 160) or 22–60 days (n = 170), and those who were ventilated for 1–2 days (n = 192). We concluded that the duration of in-hospital ventilation in patients with sepsis cannot serve as a predictor for long-term survival. Thus, the duration of ventilation in itself should not guide the level of care in ventilated patients with sepsis.

Original languageEnglish
Article number5995
JournalJournal of Clinical Medicine
Issue number20
StatePublished - 11 Oct 2022


  • intensive care unit
  • mortality
  • prolonged ventilation
  • sepsis

ASJC Scopus subject areas

  • Medicine (all)


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