Can we exchange water in a hydrate structure: A case study of etoricoxib

Sudhir Mittapalli, Geetha Bolla, Sravankumar Perumalla, Ashwini Nangia

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Novel crystalline forms of etoricoxib (ETR) with pharmaceutically acceptable coformers (generally regarded as safe, GRAS), such as glutaric acid (1 : 1), adipic acid (2 : 1), suberic acid (1 : 1), and caprolactam, were co-crystallized. The solid forms were prepared from ETR hemihydrate form I and characterized by powder XRD, DSC, and IR, and finally confirmed by single crystal X-ray diffraction. The exchange of water with an organic acid coformer in the crystal structure is explained by lattice energy calculations.

Original languageEnglish
Pages (from-to)2825-2829
Number of pages5
JournalCrystEngComm
Volume18
Issue number16
DOIs
StatePublished - 28 Apr 2016
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics

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