Canalization of tomato fruit metabolism

Saleh Alseekh, Hao Tong, Federico Scossa, Yariv Brotman, Florian Vigroux, Takayuki Tohge, Itai Ofner, Dani Zamir, Zoran Nikoloski, Alisdair R. Fernie

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

To explore the genetic robustness (canalization) of metabolism, we examined the levels of fruit metabolites in multiple harvests of a tomato introgression line (IL) population. The IL partitions the whole genome of the wild species Solanum pennellii in the background of the cultivated tomato (Solanum lycopersicum). We identified several metabolite quantitative trait loci that reduce variability for both primary and secondary metabolites, which we named canalization metabolite quantitative trait loci (cmQTL). We validated nine cmQTL using an independent population of backcross inbred lines, derived from the same parents, which allows increased resolution in mapping the QTL previously identified in the ILs. These cmQTL showed little overlap with QTL for the metabolite levels themselves. Moreover, the intervals they mapped to harbored few metabolism-associated genes, suggesting that the canalization of metabolism is largely controlled by regulatory genes.

Original languageEnglish
Pages (from-to)2753-2765
Number of pages13
JournalPlant Cell
Volume29
Issue number11
DOIs
StatePublished - 1 Nov 2017

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