Cancer in systemic sclerosis

Mahmoud Abu‐Shakra; Francis Guillemin; Peter Lee

doi:10.1002/art.1780360405

Cancer in systemic sclerosis

Mahmoud Abu‐Shakra, Francis Guillemin, Peter Lee

Research output: Contribution to journal › Article › peer-review

186 Scopus citations

Abstract

Objective. To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc). Methods. A retrospective chart review of 248 patients who were followed up prospectively was conducted. Results. Cancers developed in 18 patients (7.3%) during 2,001 patient‐years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age‐standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P > 0.0001). Conclusion. The frequency of cancer is increased in patients with SSc.

Original language	English
Pages (from-to)	460-464
Number of pages	5
Journal	Arthritis and Rheumatology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1002/art.1780360405
State	Published - 1 Jan 1993
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780360405

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title = "Cancer in systemic sclerosis",

abstract = "Objective. To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc). Methods. A retrospective chart review of 248 patients who were followed up prospectively was conducted. Results. Cancers developed in 18 patients (7.3%) during 2,001 patient‐years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age‐standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P > 0.0001). Conclusion. The frequency of cancer is increased in patients with SSc.",

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AU - Guillemin, Francis

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N2 - Objective. To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc). Methods. A retrospective chart review of 248 patients who were followed up prospectively was conducted. Results. Cancers developed in 18 patients (7.3%) during 2,001 patient‐years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age‐standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P > 0.0001). Conclusion. The frequency of cancer is increased in patients with SSc.

AB - Objective. To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc). Methods. A retrospective chart review of 248 patients who were followed up prospectively was conducted. Results. Cancers developed in 18 patients (7.3%) during 2,001 patient‐years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age‐standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P > 0.0001). Conclusion. The frequency of cancer is increased in patients with SSc.

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Cancer in systemic sclerosis

Abstract

ASJC Scopus subject areas

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