Cannabinoids and serotonin uptake by blood platelets: Evidence for multiple sites of action

Ilana Nathan, Arie Yarom, Alexander Dvilansky, Naftali Lander, Avinoam Livne

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The effect of cannabinoids on parameters of 5-hydroxytryptamine (5-HT) uptake by human platelets was examined. Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs. The pattern of inhibition did not correlate with the psychomimetic specificity of the cannabinoids.

Original languageEnglish
Pages (from-to)439-441
Number of pages3
JournalBiochemical Pharmacology
Volume31
Issue number3
DOIs
StatePublished - 1 Feb 1982

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