Cannabinoids and serotonin uptake by blood platelets: Evidence for multiple sites of action

Ilana Nathan; Arie Yarom; Alexander Dvilansky; Naftali Lander; Avinoam Livne

doi:10.1016/0006-2952(82)90195-2

Cannabinoids and serotonin uptake by blood platelets: Evidence for multiple sites of action

Ilana Nathan
, Arie Yarom
, Alexander Dvilansky
, Naftali Lander
, Avinoam Livne

Basic Sciences Divisions

Research output: Contribution to journal › Article › peer-review

7 Citations (Web of Science)

Abstract

The effect of cannabinoids on parameters of 5-hydroxytryptamine (5-HT) uptake by human platelets was examined. Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs. The pattern of inhibition did not correlate with the psychomimetic specificity of the cannabinoids.

Original language	English
Pages (from-to)	439-441
Number of pages	3
Journal	Biochemical Pharmacology
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/0006-2952(82)90195-2
State	Published - 1 Feb 1982

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/0006-2952(82)90195-2

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abstract = "The effect of cannabinoids on parameters of 5-hydroxytryptamine (5-HT) uptake by human platelets was examined. Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs. The pattern of inhibition did not correlate with the psychomimetic specificity of the cannabinoids.",

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AU - Nathan, Ilana

AU - Yarom, Arie

AU - Dvilansky, Alexander

AU - Lander, Naftali

AU - Livne, Avinoam

PY - 1982/2/1

Y1 - 1982/2/1

N2 - The effect of cannabinoids on parameters of 5-hydroxytryptamine (5-HT) uptake by human platelets was examined. Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs. The pattern of inhibition did not correlate with the psychomimetic specificity of the cannabinoids.

AB - The effect of cannabinoids on parameters of 5-hydroxytryptamine (5-HT) uptake by human platelets was examined. Natural and synthetic cannabinoids differing in the pyrene ring of the hydro-phobic side chain or in steric configuration, inhibited differentially the saturation level of 5-HT uptake, the active uptake and the passive transport of the neurotransmitter, indicating multiple sites of action of the drugs. The pattern of inhibition did not correlate with the psychomimetic specificity of the cannabinoids.

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U2 - 10.1016/0006-2952(82)90195-2

DO - 10.1016/0006-2952(82)90195-2

M3 - Article

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EP - 441

JO - Biochemical Pharmacology

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ER -

Cannabinoids and serotonin uptake by blood platelets: Evidence for multiple sites of action

Abstract

ASJC Scopus subject areas

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