Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients

Z. Volfe; A. Dvilansky; I. Nathan

Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients

Z. Volfe, A. Dvilansky, I. Nathan

Basic Sciences Divisions

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40 Scopus citations

Abstract

The effects were assessed of Δ'THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on ¹⁴C labelled serotonin release from normal platelets, when incubated with patient's plasma obtained during migraine attack. A statistically significant inhibitory effect (p > 0.005) of ¹⁴C serotonin release was found at 10^-5M, 10^-6M, 10^-7M Δ'THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on ¹⁴C serotonin release from normal platelets using the same Δ'THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on ¹⁴C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.

Original language	English
Pages (from-to)	243-246
Number of pages	4
Journal	International Journal of Clinical Pharmacology Research
Volume	5
Issue number	4
State	Published - 1 Dec 1985

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pharmacology (medical)

Cite this

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title = "Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients",

abstract = "The effects were assessed of Δ'THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on 14C labelled serotonin release from normal platelets, when incubated with patient's plasma obtained during migraine attack. A statistically significant inhibitory effect (p > 0.005) of 14C serotonin release was found at 10-5M, 10-6M, 10-7M Δ'THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on 14C serotonin release from normal platelets using the same Δ'THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.",

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T1 - Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients

AU - Volfe, Z.

AU - Dvilansky, A.

AU - Nathan, I.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - The effects were assessed of Δ'THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on 14C labelled serotonin release from normal platelets, when incubated with patient's plasma obtained during migraine attack. A statistically significant inhibitory effect (p > 0.005) of 14C serotonin release was found at 10-5M, 10-6M, 10-7M Δ'THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on 14C serotonin release from normal platelets using the same Δ'THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.

AB - The effects were assessed of Δ'THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on 14C labelled serotonin release from normal platelets, when incubated with patient's plasma obtained during migraine attack. A statistically significant inhibitory effect (p > 0.005) of 14C serotonin release was found at 10-5M, 10-6M, 10-7M Δ'THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on 14C serotonin release from normal platelets using the same Δ'THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.

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M3 - Article

AN - SCOPUS:0022416559

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JF - International Journal of Clinical Pharmacology Research

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ER -

Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients

Abstract

ASJC Scopus subject areas

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