Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients

Z. Volfe, A. Dvilansky, I. Nathan

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The effects were assessed of Δ'THC (the psychoactive component of cannabis) and CBD and DMHP-CBD (the non-psychomimetic components of marijuana derivatives) on 14C labelled serotonin release from normal platelets, when incubated with patient's plasma obtained during migraine attack. A statistically significant inhibitory effect (p > 0.005) of 14C serotonin release was found at 10-5M, 10-6M, 10-7M Δ'THC concentrations. Plasma of migraine patients obtained in attack-free periods revealed no significant inhibitory effect on 14C serotonin release from normal platelets using the same Δ'THC concentration. CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalInternational Journal of Clinical Pharmacology Research
Volume5
Issue number4
StatePublished - 1 Dec 1985

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