Cannabis-derived terpenes and flavonoids as potential pharmaceuticals

Research output: Contribution to journalReview articlepeer-review


Terpenes and flavonoids are metabolites produced by many plants, including cannabis plants. Studies suggest that combined treatment based on synergism between plant metabolites has the potential to act better than a single compound. It may be true in the case of cannabis also: the plant content may act better than 'pure' CBD. The mode of action of synergism may involve interaction of terpenes/flavonoids with CBD receptors or other receptors; as small metabolites, terpenes/flavonoids may help cannabinoids to cross dermal barrier/to be absorbed orally and/or to cross the blood-brain-barrier. This review summarize studies that discuss the mechanisms of action of terpenes and flavonoids and their effects on various human pathologies. This review cover only part of such studies with the hope to shed light on how synergism between cannabis derived terpenes and flavonoids can improve the action of cannabinoids.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalIsrael Journal of Plant Sciences
Issue number1
StatePublished - 1 Jan 2021


  • CB1/2
  • Cannabinoids
  • Cannabis
  • Flavonoids
  • G-protein
  • Synergy
  • Terpenes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Agronomy and Crop Science
  • Plant Science


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