Cannabis-derived terpenes and flavonoids as potential pharmaceuticals

Terpenes and flavonoids are metabolites produced by many plants, including cannabis plants. Studies suggest that combined treatment based on synergism between plant metabolites has the potential to act better than a single compound. It may be true in the case of cannabis also: the plant content may act better than 'pure' CBD. The mode of action of synergism may involve interaction of terpenes/flavonoids with CBD receptors or other receptors; as small metabolites, terpenes/flavonoids may help cannabinoids to cross dermal barrier/to be absorbed orally and/or to cross the blood-brain-barrier. This review summarize studies that discuss the mechanisms of action of terpenes and flavonoids and their effects on various human pathologies. This review cover only part of such studies with the hope to shed light on how synergism between cannabis derived terpenes and flavonoids can improve the action of cannabinoids.