TY - JOUR
T1 - Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid
AU - Mechoulam, Raphael
AU - Fride, Ester
AU - Ben-Shabat, Shimon
AU - Meiri, Uri
AU - Horowitz, Michal
N1 - Funding Information:
Research support by the US National Institute on Drug Abuse (DA 9789) and the Israel Science Foundation is gratefully acknowledged. We thank Ms. Judith Schleyer for technical help.
PY - 1998/11/27
Y1 - 1998/11/27
N2 - The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.
AB - The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.
KW - 2-Arachidonoyl glycerol
KW - Cannabinoid
KW - Hypotension
UR - http://www.scopus.com/inward/record.url?scp=0032407065&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(98)00777-8
DO - 10.1016/S0014-2999(98)00777-8
M3 - Article
AN - SCOPUS:0032407065
SN - 0014-2999
VL - 362
SP - R1-R3
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -