Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

Raphael Mechoulam; Ester Fride; Shimon Ben-Shabat; Uri Meiri; Michal Horowitz

doi:10.1016/S0014-2999(98)00777-8

Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

Raphael Mechoulam, Ester Fride, Shimon Ben-Shabat, Uri Meiri, Michal Horowitz

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.

Original language	English
Pages (from-to)	R1-R3
Journal	European Journal of Pharmacology
Volume	362
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(98)00777-8
State	Published - 27 Nov 1998
Externally published	Yes

Keywords

2-Arachidonoyl glycerol
Cannabinoid
Hypotension

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/S0014-2999(98)00777-8

Cite this

@article{45a9b21b17214b8a8eb99b933f8c7ffa,

title = "Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid",

abstract = "The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.",

keywords = "2-Arachidonoyl glycerol, Cannabinoid, Hypotension",

author = "Raphael Mechoulam and Ester Fride and Shimon Ben-Shabat and Uri Meiri and Michal Horowitz",

note = "Funding Information: Research support by the US National Institute on Drug Abuse (DA 9789) and the Israel Science Foundation is gratefully acknowledged. We thank Ms. Judith Schleyer for technical help.",

year = "1998",

month = nov,

day = "27",

doi = "10.1016/S0014-2999(98)00777-8",

language = "English",

volume = "362",

pages = "R1--R3",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

AU - Mechoulam, Raphael

AU - Fride, Ester

AU - Ben-Shabat, Shimon

AU - Meiri, Uri

AU - Horowitz, Michal

N1 - Funding Information: Research support by the US National Institute on Drug Abuse (DA 9789) and the Israel Science Foundation is gratefully acknowledged. We thank Ms. Judith Schleyer for technical help.

PY - 1998/11/27

Y1 - 1998/11/27

N2 - The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.

AB - The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. Copyright (C) 1998 Elsevier Science B.V.

KW - 2-Arachidonoyl glycerol

KW - Cannabinoid

KW - Hypotension

UR - http://www.scopus.com/inward/record.url?scp=0032407065&partnerID=8YFLogxK

U2 - 10.1016/S0014-2999(98)00777-8

DO - 10.1016/S0014-2999(98)00777-8

M3 - Article

AN - SCOPUS:0032407065

SN - 0014-2999

VL - 362

SP - R1-R3

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this