TY - JOUR
T1 - Carbamazepine and electroconvulsive shock attenuate β-adrenoceptor and muscarinic cholinoceptor coupling to G protein in rat cortex
AU - Avissar, Sofia
AU - Schreiber, Gabriel
AU - Aulakh, Charanjit S.
AU - Wozniak, Krystyna M.
AU - Murphy, Dennis L.
PY - 1990/7/31
Y1 - 1990/7/31
N2 - We have recently found that lithium attenuates the function of G proteins, suggesting these proteins as the common site for both the antimanic and antidepressant therapeutic effects of lithium. Perturbation of G protein function may thus be a general characteristic of treatments effective in bipolar affective disorder. In the present study, we demonstrate that both chronic carbamazepine and repeated electroconvulsive shock treatment inhibit the coupling of both muscarinic cholinoceptors and β-adrenoceptors to pertussis toxin-sensitive and cholera toxin-sensitive G proteins, respectively.
AB - We have recently found that lithium attenuates the function of G proteins, suggesting these proteins as the common site for both the antimanic and antidepressant therapeutic effects of lithium. Perturbation of G protein function may thus be a general characteristic of treatments effective in bipolar affective disorder. In the present study, we demonstrate that both chronic carbamazepine and repeated electroconvulsive shock treatment inhibit the coupling of both muscarinic cholinoceptors and β-adrenoceptors to pertussis toxin-sensitive and cholera toxin-sensitive G proteins, respectively.
KW - Carbamazepine
KW - Electroconvulsive shock
KW - G proteins
KW - Muscarinic cholinoceptors
KW - β-Adrenoceptors
UR - http://www.scopus.com/inward/record.url?scp=0025006686&partnerID=8YFLogxK
U2 - 10.1016/0922-4106(90)90235-P
DO - 10.1016/0922-4106(90)90235-P
M3 - Article
AN - SCOPUS:0025006686
SN - 0922-4106
VL - 189
SP - 99
EP - 103
JO - European Journal of Pharmacology: Molecular Pharmacology
JF - European Journal of Pharmacology: Molecular Pharmacology
IS - 1
ER -
