Carbohydrate coated, folate functionalized colloidal graphene as a nanocarrier for both hydrophobic and hydrophilic drugs

Amit Ranjan Maity, Atanu Chakraborty, Avijit Mondal, Nikhil R. Jana

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Although graphene based drug delivery has gained significant recent interest, the synthesis of colloidal graphene based nanocarriers with high drug loading capacities and with targeting ligands at the outer surface is a challenging issue. We have synthesized carbohydrate coated and folate functionalized colloidal graphene which can be used as a nanocarrier for a wide variety of hydrophobic and hydrophilic drugs. The synthesized colloidal graphene is loaded with paclitaxol, camptothecin, doxorubicin, curcumin and used for their targeted delivery to cancer cells. We demonstrate that this drug loaded functional graphene nanocarrier can successfully deliver drugs into target cells and offers an enhanced therapeutic performance. The reported approach can be extended to the cellular delivery of other hydrophobic and hydrophilic drugs and the simultaneous delivery of multiple drugs.

Original languageEnglish
Pages (from-to)2752-2758
Number of pages7
JournalNanoscale
Volume6
Issue number5
DOIs
StatePublished - 7 Mar 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science

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