Carbon-dot-hydrogel for enzyme-mediated bacterial detection

Sagarika Bhattacharya, Sukhendu Nandi, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A hybrid carbon-dot (C-dot)-hydrogel matrix was constructed and employed for detection of bacteria. The transduction mechanism is novel, based upon cleavage of ester bonds within the hydrogel scaffold by bacterially-secreted esterases; the ensuing fluidization of the hydrogel resulted in aggregation of the embedded C-dots and consequent quenching of their fluorescence. We show that the C-dot-hydrogel exhibits high sensitivity and can distinguish among bacterial species through modulation of the emitted fluorescence, depending upon their esterase secretions.

Original languageEnglish
Pages (from-to)588-594
Number of pages7
JournalRSC Advances
Volume7
Issue number2
DOIs
StatePublished - 1 Jan 2017

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