Carbon nanotubes as nanocarriers in medicine

Sivan Peretz, Oren Regev

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Carbon nanotubes (CNTs) possess outstanding properties and a unique physicochemical architecture, which may serve as an alternative platform for the delivery of various therapeutic molecules. This review focuses on recent progress in the field of CNTs for biomedical applications. After a short, general physico-chemical introduction to CNTs, we introduce different methods for CNT surface modification, facilitating their dispersions in physiological solutions, on the one hand, and binding a wide range of molecules or drug-loaded liposomes, on the other. We summarize imaging evidences on the structure of CNT-drug conjugates and their relevant uptake mechanisms by the cell. Lastly, we review current repots on CNT toxicity and new developments in CNT-based medical applications: photo-thermal therapy, drug delivery and gene therapy.

Original languageEnglish
Pages (from-to)360-368
Number of pages9
JournalCurrent Opinion in Colloid and Interface Science
Volume17
Issue number6
DOIs
StatePublished - 1 Dec 2012

Keywords

  • Carbon nanotubes
  • Drug delivery
  • Gene delivery
  • Liposome
  • Nano-carrier
  • Photothermal therapy
  • Toxicity

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry

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