Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells

Faina Karchemski, Daniel Zucker, Yechezkel Barenholz, Oren Regev

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a new drug delivery system, in which drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlled means for enhanced delivery of one or more agents stably associated with the liposomes.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalJournal of Controlled Release
Volume160
Issue number2
DOIs
StatePublished - 10 Jun 2012

Keywords

  • Carbon-nanotubes
  • Cell viability
  • Drug delivery
  • Liposome
  • TEM (transmission electron microscopy)

ASJC Scopus subject areas

  • Pharmaceutical Science

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