TY - JOUR
T1 - Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells
AU - Karchemski, Faina
AU - Zucker, Daniel
AU - Barenholz, Yechezkel
AU - Regev, Oren
N1 - Funding Information:
This study was supported by grant no. 300000–6083 from the Chief Scientist Office of the Ministry of Health, Israel to O.R. and Y.B.. Valuable discussions on organic synthesis with Dr. Yochai Dayagi and Dr. Dan Elgrabli are kindly acknowledged. Liposome preparation by Jackie Toledo is acknowledged with pleasure.
PY - 2012/6/10
Y1 - 2012/6/10
N2 - Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a new drug delivery system, in which drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlled means for enhanced delivery of one or more agents stably associated with the liposomes.
AB - Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a new drug delivery system, in which drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlled means for enhanced delivery of one or more agents stably associated with the liposomes.
KW - Carbon-nanotubes
KW - Cell viability
KW - Drug delivery
KW - Liposome
KW - TEM (transmission electron microscopy)
UR - http://www.scopus.com/inward/record.url?scp=84861699759&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2011.12.037
DO - 10.1016/j.jconrel.2011.12.037
M3 - Article
AN - SCOPUS:84861699759
SN - 0168-3659
VL - 160
SP - 339
EP - 345
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 2
ER -