Cardiac and cardiovascular morbidities in patients with psoriatic arthritis: a population-based case control study

Adi Kibari, Arnon D. Cohen, Tal Gazitt, Haim Bitterman, Idit Lavi, Ilan Feldhamer, Guy Shalom, Sari Greenberg-Dotan, Devy Zisman

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Objective: To assess the prevalence of risk factors associated with cardiovascular disease (CVD) and CVD-related morbidity in a large Middle-Eastern psoriatic arthritis (PsA) cohort. Method: A retrospective case control study was conducted using Israel’s largest health care provider’s patient database from 2000 to 2013. For each patient with PsA, 10 patients with no history of psoriasis or arthritis were matched for age and sex. Analysis of CVD-related risk factors and morbidity included hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus type 2 (DM-2), obesity, smoking, ischemic heart disease (IHD), congestive heart failure (CHF), cerebrovascular accident (CVA), carotid artery disease, peripheral vascular disease (PVD), aortic aneurism, valvular heart disease (VHD), and cardiomyopathy. Statistical analysis was conducted using t test and chi-square tests as appropriate. Univariate and multivariable logistic regression models assessed the association between PsA and CVD-related risk factors and morbidity. Results: Three thousand one hundred sixty-one PsA patients were included, with average age 58 ± 15.0 years, of whom 53.4% were women. Increased prevalence of DM-2, HLD, HTN, and obesity (OR 1.7, 1.5, 1.5, 1.5 respectively) was noted in the PsA group. Increased prevalence of IHD (p < 0.0001), PVD (p < 0.0001), CHF (p = 0.002), VHD (p < 0.0001), and cardiomyopathy (p = 0.006) was found in the PsA group compared to the control group even after adjusting for CVD risk factors. Conclusions: A high prevalence of CVD-related risk factors and morbidity was found in this Middle Eastern PsA population, in accordance with data from other geographic regions. These results emphasize the importance of clinician awareness of the increased risk for CVD-related complications in PsA patients.

    Original languageEnglish
    Pages (from-to)2069-2075
    Number of pages7
    JournalClinical Rheumatology
    Volume38
    Issue number8
    DOIs
    StatePublished - 1 Aug 2019

    Keywords

    • CVD-related morbidity
    • Cardiovascular disease (CVD) risk factors
    • Psoriatic arthritis (PsA)

    ASJC Scopus subject areas

    • Rheumatology

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