Cardiac tissue engineering, ex-vivo: Design principles in biomaterials and bioreactors

Michal Shackar, Smadar Cohen

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


Cardiac tissue engineering has emerged as a promising approach to replace or support an infarcted cardiac tissue and thus may hold a great potential to treat and save the lives of patients with heart diseases. By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within 3-D biomaterials, then culturing and implanting the cell-seeded scaffolds to induce and direct the growth of new, healthy tissue. In this review, we present an up-to-date summary of the research in cardiac tissue engineering, with an emphasis on the design principles and selection criteria that have been used in two key technologies employed in tissue engineering, (1) biomaterials technology, for the creation of 3-D porous scaffolds which are used to support and guide the tissue formation from dissociated cells, and (2) bioreactor cultivation of the 3-D cell constructs during ex-vivo tissue engineering, which aims to duplicate the normal stresses and flows experienced by the tissues.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalHeart Failure Reviews
Issue number3
StatePublished - 1 Jul 2003


  • Biomaterials
  • Bioreactors
  • Cardiac muscle
  • Heart failure
  • Tissue engineering

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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