Cardiolipin mediates curcumin interactions with mitochondrial membranes

Shani Ben-Zichri, Sofiya Kolusheva, Michael Danilenko, Saniya Ossikbayeva, William J. Stabbert, Juan L. Poggio, David E. Stein, Zulfiya Orynbayeva, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Curcumin, the main molecular ingredient of the turmeric spice, has been reported to exhibit therapeutic properties for varied diseases and pathological conditions. While curcumin appears to trigger multiple signaling pathways, the precise mechanisms accounting for its therapeutic activity have not been deciphered. Here we show that curcumin exhibits significant interactions with cardiolipin (CL), a lipid exclusively residing in the mitochondrial membrane. Specifically, we found that curcumin affected the structures and dynamics of CL-containing biomimetic and biological mitochondrial membranes. Application of several biophysical techniques reveals the CL-promoted association and internalization of curcumin into lipid bilayers. In parallel, curcumin association with CL containing bilayers increased their fluidity and reduced lipid ordering. These findings suggest that membrane modifications mediated by CL interactions may play a role in the therapeutic functions of curcumin, and that the inner mitochondrial membrane in general might constitute a potential drug target.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1861
Issue number1
DOIs
StatePublished - 1 Jan 2019

Keywords

  • Cardiolipin
  • Curcumin
  • Metabolism
  • Mitochondrial membranes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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