TY - JOUR
T1 - Cardiopulmonary exercise testing in adolescence following extremely premature birth
AU - Amitai, Nofar
AU - Stafler, Patrick
AU - Blau, Hannah
AU - Kaplan, Eytan
AU - Mussaffi, Huda
AU - Levine, Hagit
AU - Bar-On, Ophir
AU - Steuer, Guy
AU - Bar-Yishay, Ephraim
AU - Klinger, Gil
AU - Mei-Zahav, Meir
AU - Prais, Dario
N1 - Publisher Copyright:
© 2024 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Background: Although extremely premature birth disrupts lung development, adolescent survivors of extreme prematurity show good clinical and physiologic outcomes. Cardiopulmonary limitations may not be clinically evident at rest. Data regarding exercise limitation in adolescents following preterm birth in the postsurfactant era are limited. Research Question: What are the long-term effects of bronchopulmonary dysplasia (BPD) and extreme prematurity (<29 weeks) on ventilatory response during exercise in adolescents in the postsurfactant era?. Study Design and Methods: We followed a longitudinally recruited cohort of children aged 13–19 years who were born at a gestational age of <29 weeks (study group - SG). We compared the cardiopulmonary exercise testing (CPET) results of those with and without BPD, to their own CPET results from elementary school age (mean 9.09 ± 1.05 years). Results: Thirty-seven children aged 15.73 ± 1.31 years, mean gestational age 26 weeks (± 1.19), completed the study. CPET parameters in adolescence were within the normal range for age, including mean V̇O2 peak of 91% predicted. The BPD and non-BPD subgroups had similar results. In the longitudinal analysis of the SG, improvement was observed in adolescence, compared with elementary school age, in breathing reserve (36.37 ± 18.99 vs. 26.58 ± 17.92, p = 0.044), tidal volume as a fraction of vital capacity achieved at maximal load (0.51 ± 0.13 vs. 0.37 ± 0.08, p < 0.001), and respiratory exchange ratio at maximal load (1.18 ± 0.13 vs. 1.11 ± 0.10, p = 0.021). Interpretation: In the current cohort, adolescents born extremely premature have essentially normal ventilatory response during exercise, unrelated to BPD diagnosis. CPET results in this population improve over time.
AB - Background: Although extremely premature birth disrupts lung development, adolescent survivors of extreme prematurity show good clinical and physiologic outcomes. Cardiopulmonary limitations may not be clinically evident at rest. Data regarding exercise limitation in adolescents following preterm birth in the postsurfactant era are limited. Research Question: What are the long-term effects of bronchopulmonary dysplasia (BPD) and extreme prematurity (<29 weeks) on ventilatory response during exercise in adolescents in the postsurfactant era?. Study Design and Methods: We followed a longitudinally recruited cohort of children aged 13–19 years who were born at a gestational age of <29 weeks (study group - SG). We compared the cardiopulmonary exercise testing (CPET) results of those with and without BPD, to their own CPET results from elementary school age (mean 9.09 ± 1.05 years). Results: Thirty-seven children aged 15.73 ± 1.31 years, mean gestational age 26 weeks (± 1.19), completed the study. CPET parameters in adolescence were within the normal range for age, including mean V̇O2 peak of 91% predicted. The BPD and non-BPD subgroups had similar results. In the longitudinal analysis of the SG, improvement was observed in adolescence, compared with elementary school age, in breathing reserve (36.37 ± 18.99 vs. 26.58 ± 17.92, p = 0.044), tidal volume as a fraction of vital capacity achieved at maximal load (0.51 ± 0.13 vs. 0.37 ± 0.08, p < 0.001), and respiratory exchange ratio at maximal load (1.18 ± 0.13 vs. 1.11 ± 0.10, p = 0.021). Interpretation: In the current cohort, adolescents born extremely premature have essentially normal ventilatory response during exercise, unrelated to BPD diagnosis. CPET results in this population improve over time.
KW - bronchopulmonary dysplasia
KW - cardiopulmonary exercise testing
KW - extreme prematurity
KW - pulmonary function
UR - http://www.scopus.com/inward/record.url?scp=85188939021&partnerID=8YFLogxK
U2 - 10.1002/ppul.26867
DO - 10.1002/ppul.26867
M3 - Article
C2 - 38240499
AN - SCOPUS:85188939021
SN - 8755-6863
VL - 59
SP - 997
EP - 1005
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 4
ER -