Cardiovascular and metabolic risk factors in inherited auto inflammation

Gilad Twig; Avi Livneh; Asaf Vivante; Arnon Afek; Estela Derazne; Adi Leiba; Dana Ben Ami Shor; Chanan Meydan; Ilan Ben-Zvi; Dorit Tzur; Ariel Furer; Massimo Imazio; Yehuda Adler; Howard Amital

doi:10.1210/jc.2014-2096

Cardiovascular and metabolic risk factors in inherited auto inflammation

Gilad Twig, Avi Livneh, Asaf Vivante, Arnon Afek, Estela Derazne, Adi Leiba, Dana Ben Ami Shor, Chanan Meydan, Ilan Ben-Zvi, Dorit Tzur, Ariel Furer, Massimo Imazio, Yehuda Adler, Howard Amital

Research output: Contribution to journal › Article › peer-review

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Abstract

Results; In multivariable regression analysis adjusted for known confounders of obesity, FMF participants had an odds ratio of 0.65 forthe occurrence of overweight [95% confidence interval (CI) 0.44-0.96, P=.03] and 0.66 (95% CI 0.48-0.92, P =.012) for hypertension-range BP; their siblings tended to obesity (odds ratio 1.48; 95% CI1.04-2.11, P=.008). In thefollow-up arm, a multivariable analysis adjusted for age, birthyear, BMI, education, socioeconomicstatus, ethnicity, and physical activityyielded hazard ratios of 0.32 (95% CI 0.10-0.82, P=.002) for incident obesity, 0.49(95% CI 0.25-0.95, P=.037) for incident triglycerides 150 mg/dL or greater, 0.56 (95% CI 0.31-0.98, P =.048) for low-density lipoprotein cholesterol 130 mg/dL or greater, and 2.14(1.368-3.359, P=.001) for high-density lipoprotein cholesterol less than 40 mg/dL for FMF participants compared with controls. Incident elevated BP was lower among FMF participants (hazard ratio 0.49; 95% CI 0.23-1.00, P =.05), where as dysglycemia incidence was comparable.

Conclusions: FMFis associated with lower rates of most components of the metabolicsyndrome compared with normal subjects, unlike other inflammatory conditions.

Context: The natural progression of metabolic abnormalities among patients with inherited auto inflammation is unclear.

Objective: The objective of the study was to assess the cardiometabolic risk of participants with familial Mediterranean fever (FMF).

Design and Setting: This study included nationwide cross-sectional and longitudinal cohorts.

Participants: The prevalence of components of the metabolic syndrome at age 17 years was assessed from the medical database of the Israeli Defense Force from 1973 through 1997. Included were 745 males with FMF, 902 healthy male siblings, and a control group of 787 714 participants. A prospective follow-up study traced the incidence of components of the metabolic syndrome to age 45 years among 57 FMF and 1568 control army personnel participants.

Interventions: Body mass index (BMI) and blood pressure (BP) were measured at age 17 years (crosssectional); lifestyle, anthropometric, and biochemical data were periodically recorded from age 25 years.

Main Outcome Measures: Abnormal BMI or BP (age 17y) and Adult Treatment Panel III criteria of the metabolic syndrome were measured.

Original language	English
Pages (from-to)	E2123-E2128
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	99
Issue number	10
DOIs	https://doi.org/10.1210/jc.2014-2096
State	Published - 1 Oct 2014
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jc.2014-2096

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@article{c8c78c75c4f4470cbf67a1f444a9affc,

title = "Cardiovascular and metabolic risk factors in inherited auto inflammation",

abstract = "Results; In multivariable regression analysis adjusted for known confounders of obesity, FMF participants had an odds ratio of 0.65 forthe occurrence of overweight [95% confidence interval (CI) 0.44-0.96, P=.03] and 0.66 (95% CI 0.48-0.92, P =.012) for hypertension-range BP; their siblings tended to obesity (odds ratio 1.48; 95% CI1.04-2.11, P=.008). In thefollow-up arm, a multivariable analysis adjusted for age, birthyear, BMI, education, socioeconomicstatus, ethnicity, and physical activityyielded hazard ratios of 0.32 (95% CI 0.10-0.82, P=.002) for incident obesity, 0.49(95% CI 0.25-0.95, P=.037) for incident triglycerides 150 mg/dL or greater, 0.56 (95% CI 0.31-0.98, P =.048) for low-density lipoprotein cholesterol 130 mg/dL or greater, and 2.14(1.368-3.359, P=.001) for high-density lipoprotein cholesterol less than 40 mg/dL for FMF participants compared with controls. Incident elevated BP was lower among FMF participants (hazard ratio 0.49; 95% CI 0.23-1.00, P =.05), where as dysglycemia incidence was comparable.Conclusions: FMFis associated with lower rates of most components of the metabolicsyndrome compared with normal subjects, unlike other inflammatory conditions.Context: The natural progression of metabolic abnormalities among patients with inherited auto inflammation is unclear.Objective: The objective of the study was to assess the cardiometabolic risk of participants with familial Mediterranean fever (FMF).Design and Setting: This study included nationwide cross-sectional and longitudinal cohorts.Participants: The prevalence of components of the metabolic syndrome at age 17 years was assessed from the medical database of the Israeli Defense Force from 1973 through 1997. Included were 745 males with FMF, 902 healthy male siblings, and a control group of 787 714 participants. A prospective follow-up study traced the incidence of components of the metabolic syndrome to age 45 years among 57 FMF and 1568 control army personnel participants.Interventions: Body mass index (BMI) and blood pressure (BP) were measured at age 17 years (crosssectional); lifestyle, anthropometric, and biochemical data were periodically recorded from age 25 years.Main Outcome Measures: Abnormal BMI or BP (age 17y) and Adult Treatment Panel III criteria of the metabolic syndrome were measured.",

author = "Gilad Twig and Avi Livneh and Asaf Vivante and Arnon Afek and Estela Derazne and Adi Leiba and Shor, {Dana Ben Ami} and Chanan Meydan and Ilan Ben-Zvi and Dorit Tzur and Ariel Furer and Massimo Imazio and Yehuda Adler and Howard Amital",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 by the Endocrine Society.",

year = "2014",

month = oct,

day = "1",

doi = "10.1210/jc.2014-2096",

language = "English",

volume = "99",

pages = "E2123--E2128",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

number = "10",

}

TY - JOUR

T1 - Cardiovascular and metabolic risk factors in inherited auto inflammation

AU - Twig, Gilad

AU - Livneh, Avi

AU - Vivante, Asaf

AU - Afek, Arnon

AU - Derazne, Estela

AU - Leiba, Adi

AU - Shor, Dana Ben Ami

AU - Meydan, Chanan

AU - Ben-Zvi, Ilan

AU - Tzur, Dorit

AU - Furer, Ariel

AU - Imazio, Massimo

AU - Adler, Yehuda

AU - Amital, Howard

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Results; In multivariable regression analysis adjusted for known confounders of obesity, FMF participants had an odds ratio of 0.65 forthe occurrence of overweight [95% confidence interval (CI) 0.44-0.96, P=.03] and 0.66 (95% CI 0.48-0.92, P =.012) for hypertension-range BP; their siblings tended to obesity (odds ratio 1.48; 95% CI1.04-2.11, P=.008). In thefollow-up arm, a multivariable analysis adjusted for age, birthyear, BMI, education, socioeconomicstatus, ethnicity, and physical activityyielded hazard ratios of 0.32 (95% CI 0.10-0.82, P=.002) for incident obesity, 0.49(95% CI 0.25-0.95, P=.037) for incident triglycerides 150 mg/dL or greater, 0.56 (95% CI 0.31-0.98, P =.048) for low-density lipoprotein cholesterol 130 mg/dL or greater, and 2.14(1.368-3.359, P=.001) for high-density lipoprotein cholesterol less than 40 mg/dL for FMF participants compared with controls. Incident elevated BP was lower among FMF participants (hazard ratio 0.49; 95% CI 0.23-1.00, P =.05), where as dysglycemia incidence was comparable.Conclusions: FMFis associated with lower rates of most components of the metabolicsyndrome compared with normal subjects, unlike other inflammatory conditions.Context: The natural progression of metabolic abnormalities among patients with inherited auto inflammation is unclear.Objective: The objective of the study was to assess the cardiometabolic risk of participants with familial Mediterranean fever (FMF).Design and Setting: This study included nationwide cross-sectional and longitudinal cohorts.Participants: The prevalence of components of the metabolic syndrome at age 17 years was assessed from the medical database of the Israeli Defense Force from 1973 through 1997. Included were 745 males with FMF, 902 healthy male siblings, and a control group of 787 714 participants. A prospective follow-up study traced the incidence of components of the metabolic syndrome to age 45 years among 57 FMF and 1568 control army personnel participants.Interventions: Body mass index (BMI) and blood pressure (BP) were measured at age 17 years (crosssectional); lifestyle, anthropometric, and biochemical data were periodically recorded from age 25 years.Main Outcome Measures: Abnormal BMI or BP (age 17y) and Adult Treatment Panel III criteria of the metabolic syndrome were measured.

AB - Results; In multivariable regression analysis adjusted for known confounders of obesity, FMF participants had an odds ratio of 0.65 forthe occurrence of overweight [95% confidence interval (CI) 0.44-0.96, P=.03] and 0.66 (95% CI 0.48-0.92, P =.012) for hypertension-range BP; their siblings tended to obesity (odds ratio 1.48; 95% CI1.04-2.11, P=.008). In thefollow-up arm, a multivariable analysis adjusted for age, birthyear, BMI, education, socioeconomicstatus, ethnicity, and physical activityyielded hazard ratios of 0.32 (95% CI 0.10-0.82, P=.002) for incident obesity, 0.49(95% CI 0.25-0.95, P=.037) for incident triglycerides 150 mg/dL or greater, 0.56 (95% CI 0.31-0.98, P =.048) for low-density lipoprotein cholesterol 130 mg/dL or greater, and 2.14(1.368-3.359, P=.001) for high-density lipoprotein cholesterol less than 40 mg/dL for FMF participants compared with controls. Incident elevated BP was lower among FMF participants (hazard ratio 0.49; 95% CI 0.23-1.00, P =.05), where as dysglycemia incidence was comparable.Conclusions: FMFis associated with lower rates of most components of the metabolicsyndrome compared with normal subjects, unlike other inflammatory conditions.Context: The natural progression of metabolic abnormalities among patients with inherited auto inflammation is unclear.Objective: The objective of the study was to assess the cardiometabolic risk of participants with familial Mediterranean fever (FMF).Design and Setting: This study included nationwide cross-sectional and longitudinal cohorts.Participants: The prevalence of components of the metabolic syndrome at age 17 years was assessed from the medical database of the Israeli Defense Force from 1973 through 1997. Included were 745 males with FMF, 902 healthy male siblings, and a control group of 787 714 participants. A prospective follow-up study traced the incidence of components of the metabolic syndrome to age 45 years among 57 FMF and 1568 control army personnel participants.Interventions: Body mass index (BMI) and blood pressure (BP) were measured at age 17 years (crosssectional); lifestyle, anthropometric, and biochemical data were periodically recorded from age 25 years.Main Outcome Measures: Abnormal BMI or BP (age 17y) and Adult Treatment Panel III criteria of the metabolic syndrome were measured.

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U2 - 10.1210/jc.2014-2096

DO - 10.1210/jc.2014-2096

M3 - Article

C2 - 25062460

AN - SCOPUS:84907601708

SN - 0021-972X

VL - 99

SP - E2123-E2128

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 10

ER -

Cardiovascular and metabolic risk factors in inherited auto inflammation

Abstract

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UN SDGs

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