Carotid artery intima-media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis

Yaniv Sherer, Christian Pagnoux, Gilles Chironi, Alain Simon, Loïc Guillevin, Luc Mouthon, Boris Gilburd, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima-media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.

Original languageEnglish
Pages (from-to)1099-1103
Number of pages5
JournalRheumatology International
Volume28
Issue number11
DOIs
StatePublished - 1 Sep 2008
Externally publishedYes

Keywords

  • Autoantibody
  • Heat shock protein-60
  • Heat shock protein-65
  • Oxidized low-density lipoprotein
  • Vasculitis

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