TY - JOUR
T1 - Carrier-mediated uptake of LevoXoxacin by Befio cells, a human trophoblast cell line
AU - Polachek, Hana
AU - Holcberg, Gershon
AU - Rubin, Joseph Polachek Mazal
AU - Feinshtein, Valeria
AU - Sheiner, Eyal
AU - Ben-Zvi, Zvi
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Objective Placental transfer of LevoXoxacin (LF), a broad spectrum fluoroquinolone antibiotic, and its inhibition was investigated in Befio cells, a human trophoblast cell line. Methods The experiments of LF uptake by Befio cells were performed after preincubation and in the presence of the P-glycoprotein inhibitors (Cyclosporin A, Verapamil and Quercetin), the organic anion/cation transporter inhibitor (Cimetidine) and the MCT substrates (lactic acid and salicylic acid).
AB - Objective Placental transfer of LevoXoxacin (LF), a broad spectrum fluoroquinolone antibiotic, and its inhibition was investigated in Befio cells, a human trophoblast cell line. Methods The experiments of LF uptake by Befio cells were performed after preincubation and in the presence of the P-glycoprotein inhibitors (Cyclosporin A, Verapamil and Quercetin), the organic anion/cation transporter inhibitor (Cimetidine) and the MCT substrates (lactic acid and salicylic acid).
UR - https://www.scopus.com/pages/publications/77950627062
U2 - 10.1007/s00404-009-1177-y
DO - 10.1007/s00404-009-1177-y
M3 - Article
C2 - 19629508
AN - SCOPUS:77950627062
SN - 0932-0067
VL - 281
SP - 833
EP - 838
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 5
ER -