Case-referent study on occupational risk factors for bladder cancer in southern Israel

R. Carel, A. Levitas-Langman, E. Kordysh, J. Goldsmith, M. Friger

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: To evaluate the possible association between occupational exposures (risk factors) and male bladder cancer in the Negev region (southern Israel) to enable preventive strategies to be applied. Methods: A total of 92 male bladder cancer patients, diagnosed at a regional medical center between 1989 and 1993, were studied by interview and compared with 92 males without oncological disease after matching by age and country of origin. A special questionnaire was developed to gather information on demography, life-time occupational history, smoking habits, coffee consumption, and health status. Statistical analysis of the case-referent data was done using the SPSS-5 package for performance of the chi-square test, conditional logistic regression, and multiple classification analysis. Results: Significant associations were found between bladder cancer occurrence and (1) three different groups of occupational exposures [a - solvents (P = 0.002, OR not computed due to the lack of exposed persons among referents), b - dusts (P = 0.02; OR = 4.67), and c - exposure to multiple chemicals (P < 0.001, OR = 6.25); (2) nephrolithiasis (P = 0.02, OR = 11.00); and (3) cigarette smoking (P = 0.01, OR = 1.87). Conclusions: Certain types of occupational exposure, different from that to aromatic amines and dyes, may be considered as contributing factors in the epidemiology of bladder cancer. Better identification of these chemicals and the work processes where they are used may help in abating such exposures, thus leading to a reduction in the risk for this relatively common cancer.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalInternational Archives of Occupational and Environmental Health
Issue number5
StatePublished - 1 Aug 1999


  • Bladder cancer
  • Case-referent study
  • Cigarette smoking
  • Nephrolithiasis
  • Occupational risk factors
  • Solvent exposure

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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