Case report of increased exposure to antiretrovirals following sleeve gastrectomy

Sarah Israel, Hila Elinav, Ram Elazary, Daniel Porat, Roni Gibori, Arik Dahan, Carmil Azran, Ehud Horwitz

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of a morbidly obese HIV patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic drug monitoring was performed at several time points pre- and postsurgery. Significantly increased levels were measured, particularly for abacavir, whose levels increased ~12-fold. Several mechanistic explanations for these findings are discussed.

Original languageEnglish
Article numbere02453-19
JournalAntimicrobial Agents and Chemotherapy
Volume64
Issue number4
DOIs
StatePublished - 1 Jan 2020

Keywords

  • Antiretrovirals
  • Bariatric surgery
  • Obesity
  • Sleeve gastrectomy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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