TY - JOUR
T1 - Case Series of Myocarditis Following mRNA COVID Vaccine Compared to Pediatric Multisystem Inflammatory Syndrome
T2 - Multicenter Retrospective Study
AU - Butbul Aviel, Yonatan
AU - Hashkes, Philip J.
AU - Dizitzer, Yotam
AU - Inbar, Kanteman
AU - Berkun, Yackov
AU - Eisenstein, Eli M.
AU - Hamad Saied, Mohamad
AU - Goldzweig, Ofra
AU - Heshin-Bekenstein, Merav
AU - Ling, Eduard
AU - Feldon, Michal
AU - Tal, Rotem
AU - Pinchevski-Kadir, Shiran
AU - Tirosh, Irit
AU - Harel, Liora
AU - Amarilyo, Gil
AU - Kaidar, Kfir
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Introduction: Since the development of COVID-19 vaccines, more than 4.8 billion people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases of myocarditis following the second vaccine dose emerged. This study aimed to report our experience with adolescent and young adults who developed post-COVID-19 vaccine myocarditis and to compare these patients to a cohort of patients who acquired pediatric inflammatory multisystem syndrome (PIMS/PIMS-TS) post-COVID-19 infection. Methods: We collected reported cases of patients who developed myocarditis following COVID-19 vaccination (Pfizer mRNA BNT162b2) from all pediatric rheumatology centers in Israel and compared them to a cohort of patients with PIMS. Results: Nine patients with post-vaccination myocarditis were identified and compared to 78 patients diagnosed with PIMS. All patients with post-vaccination myocarditis were males who developed symptoms following their second dose of the vaccine. Patients with post-vaccination myocarditis had a shorter duration of stay in the hospital (mean 4.4 ± 1.9 vs. 8.7 ± 4.7 days) and less myocardial dysfunction (11.1% vs. 61.5%), and all had excellent outcomes as compared to the chronic changes among 9.2% of the patients with PIMS. Conclusion: The clinical course of vaccine-associated myocarditis appears favorable, with resolution of the symptoms in all the patients in our cohort.
AB - Introduction: Since the development of COVID-19 vaccines, more than 4.8 billion people have been immunized worldwide. Soon after vaccinations were initiated, reports on cases of myocarditis following the second vaccine dose emerged. This study aimed to report our experience with adolescent and young adults who developed post-COVID-19 vaccine myocarditis and to compare these patients to a cohort of patients who acquired pediatric inflammatory multisystem syndrome (PIMS/PIMS-TS) post-COVID-19 infection. Methods: We collected reported cases of patients who developed myocarditis following COVID-19 vaccination (Pfizer mRNA BNT162b2) from all pediatric rheumatology centers in Israel and compared them to a cohort of patients with PIMS. Results: Nine patients with post-vaccination myocarditis were identified and compared to 78 patients diagnosed with PIMS. All patients with post-vaccination myocarditis were males who developed symptoms following their second dose of the vaccine. Patients with post-vaccination myocarditis had a shorter duration of stay in the hospital (mean 4.4 ± 1.9 vs. 8.7 ± 4.7 days) and less myocardial dysfunction (11.1% vs. 61.5%), and all had excellent outcomes as compared to the chronic changes among 9.2% of the patients with PIMS. Conclusion: The clinical course of vaccine-associated myocarditis appears favorable, with resolution of the symptoms in all the patients in our cohort.
KW - COVID vaccine
KW - PIMS
KW - myocarditis
UR - http://www.scopus.com/inward/record.url?scp=85137411877&partnerID=8YFLogxK
U2 - 10.3390/vaccines10081207
DO - 10.3390/vaccines10081207
M3 - Article
AN - SCOPUS:85137411877
SN - 2076-393X
VL - 10
JO - Vaccines
JF - Vaccines
IS - 8
M1 - 1207
ER -