Catalytic physiological amyloids

Elad Arad, Raz Jelinek

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Amyloid fibrils have been identified in many protein systems, mostly linked to progression and cytotoxicity in neurodegenerative diseases and other pathologies, but have also been observed in normal physiological systems. A growing body of work has shown that amyloid fibrils can catalyze chemical reactions. Most studies have focused on catalysis by de-novo synthetic amyloid-like peptides; however, recent studies reveal that physiological, native amyloids are catalytic as well. Here, we discuss methodologies and major experimental aspects pertaining to physiological catalytic amyloids. We highlight analyzes of kinetic parameters related to the catalytic activities of amyloid fibrils, structure-function considerations, characterization of the catalytic active sites, and deciphering of catalytic mechanisms.

Original languageEnglish
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
DOIs
StateAccepted/In press - 1 Jan 2024

Publication series

NameMethods in Enzymology
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Amyloid diseases
  • Amyloid fibrils
  • Antibiotic resistance
  • Beta-lactams
  • Catalytic amyloids
  • Para-nitrophenol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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