Cbx4: A new guardian of p63's domain of epidermal control

Idan Cohen; Elena Ezhkova

doi:10.1083/jcb.201512032

Cbx4: A new guardian of p63's domain of epidermal control

Idan Cohen, Elena Ezhkova

Research output: Contribution to journal › Comment/debate

6 Scopus citations

Abstract

Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.

Original language	English
Pages (from-to)	9-11
Number of pages	3
Journal	Journal of Cell Biology
Volume	212
Issue number	1
DOIs	https://doi.org/10.1083/jcb.201512032
State	Published - 1 Jan 2016
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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title = "Cbx4: A new guardian of p63's domain of epidermal control",

abstract = "Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.",

author = "Idan Cohen and Elena Ezhkova",

note = "Publisher Copyright: {\textcopyright} 2016 Cohen and Ezhkova.",

year = "2016",

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AU - Ezhkova, Elena

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AB - Epigenetic regulators are essential for cell lineage choices during development. In this issue, Mardaryev et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506065) show that Polycomb subunit Cbx4 acts downstream of transcriptional regulator p63 to maintain epidermal progenitor identity and proliferation in the developing epidermis via Polycomb-dependent and -independent SUMO E3 ligase activities.

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M3 - Comment/debate

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JO - Journal of Cell Biology

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Cbx4: A new guardian of p63's domain of epidermal control

Abstract

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