Ccomposiciones de péptidos HSP60 y antígenos víricos para vacunación y diagnóstico

Irun Cohen (Inventor), Bracha Rager-Zisman (Inventor), Angel Porgador (Inventor), Johannes Herkel (Inventor)

Research output: Patent


Composición de vacuna que comprende un antígeno y un adyuvante de péptido sintéticoKKARVEDALHATRAAVEEGV (Ec27; SEC ID Nº: 76). The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses.

Original languageSpanish
Patent numberES2389849T
IPCC12Q 1/ 70 A I
Priority date21/02/06
StatePublished - 2 Nov 2012

Cite this