Celecoxib cocrystal polymorphs with cyclic amides: Synthons of a sulfonamide drug with carboxamide coformers

Geetha Bolla; Sudhir Mittapalli; Ashwini Nangia

doi:10.1039/c3ce41885e

Celecoxib cocrystal polymorphs with cyclic amides: Synthons of a sulfonamide drug with carboxamide coformers

Geetha Bolla, Sudhir Mittapalli, Ashwini Nangia

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The trimorphic cocrystals of celecoxib with δ-valerolactam contain sulfonamide dimers and catemers together with carboxamide dimers, whereas the caprolactam cocrystal is sustained by a SO₂N-H⋯H-NOC heterosynthon. The alternation of synthons with even-odd ring coformers offers a crystal engineering approach to sulfonamide-carboxamide cocrystals.

Original language	English
Pages (from-to)	24-27
Number of pages	4
Journal	CrystEngComm
Volume	16
Issue number	1
DOIs	https://doi.org/10.1039/c3ce41885e
State	Published - 7 Jan 2014
Externally published	Yes

ASJC Scopus subject areas

Chemistry (all)
Materials Science (all)
Condensed Matter Physics

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abstract = "The trimorphic cocrystals of celecoxib with δ-valerolactam contain sulfonamide dimers and catemers together with carboxamide dimers, whereas the caprolactam cocrystal is sustained by a SO2N-H⋯H-NOC heterosynthon. The alternation of synthons with even-odd ring coformers offers a crystal engineering approach to sulfonamide-carboxamide cocrystals.",

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AB - The trimorphic cocrystals of celecoxib with δ-valerolactam contain sulfonamide dimers and catemers together with carboxamide dimers, whereas the caprolactam cocrystal is sustained by a SO2N-H⋯H-NOC heterosynthon. The alternation of synthons with even-odd ring coformers offers a crystal engineering approach to sulfonamide-carboxamide cocrystals.

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Celecoxib cocrystal polymorphs with cyclic amides: Synthons of a sulfonamide drug with carboxamide coformers

Abstract

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