Cell mediated immunity and effects of “thymic humoral factor” in 15 patients with SSPE

Zeev T. Handzel, Natan Gadoth, Dalia Idar, Menachem Schlesinger, Esther Kahana, Ron Dagan, Stanley Levin, Natan Trainin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Cell mediated immunity (CMI) in 15 patients with subacute sclerosing panencephalitis (SSPE) was assessed by E-rosette formation, leucocyte migration inhibition factor (LIF) production, and proliferative responses to mitogens. In eleven patients, one or more of these parameters were impaired. These defects varied among the different patients and no consistent or uniform pattern of immune deficiency could be demonstrated. Although no single patient had a generalized reduction of all the T-cell functions, a diminished percentage of E-rosetting cells was the most frequent abnormal parameter (7 out of 15 patients). There was no correlation between the clinical state of the patients and the immune defects. Thymic humoral factor (THF), a thymic hormone, reconstituted at least one CMI impaired function especially the reduced levels of E-rosette forming cells in 7 out of 9 patients. It seems unlikely that a generalized cell-mediated defect is the underlying cause of this disease, but immunomodulatory therapy should be considered in some selected cases.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalBrain and Development
Volume5
Issue number1
DOIs
StatePublished - 1 Jan 1983
Externally publishedYes

Keywords

  • Measles
  • THF
  • cell mediated immunity
  • immune defects
  • sclerosing panencephalitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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