Cells, scaffolds, and molecules for myocardial tissue engineering

Jonathan Leor; Yoram Amsalem; Smadar Cohen

doi:10.1016/j.pharmthera.2004.10.003

Cells, scaffolds, and molecules for myocardial tissue engineering

Jonathan Leor, Yoram Amsalem, Smadar Cohen

Department of Biotechnology Engineering

Research output: Contribution to journal › Review article › peer-review

302 Scopus citations

Abstract

Unlike heart valves or blood vessels, heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors, and the synthesis of bioactive materials promise to create engineered cardiac tissue ex vivo. At the same time, new approaches are conceived that explore ways to induce tissue regeneration after injury. The purpose of our review is to describe the principles, status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration.

Original language	English
Pages (from-to)	151-163
Number of pages	13
Journal	Pharmacology and Therapeutics
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.pharmthera.2004.10.003
State	Published - 1 Feb 2005

Keywords

Biomaterial
Cell
Heart
Scaffold
Tissue engineering
Transplantation

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pharmthera.2004.10.003

Cite this

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title = "Cells, scaffolds, and molecules for myocardial tissue engineering",

abstract = "Unlike heart valves or blood vessels, heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors, and the synthesis of bioactive materials promise to create engineered cardiac tissue ex vivo. At the same time, new approaches are conceived that explore ways to induce tissue regeneration after injury. The purpose of our review is to describe the principles, status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration.",

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AU - Leor, Jonathan

AU - Amsalem, Yoram

AU - Cohen, Smadar

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N2 - Unlike heart valves or blood vessels, heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors, and the synthesis of bioactive materials promise to create engineered cardiac tissue ex vivo. At the same time, new approaches are conceived that explore ways to induce tissue regeneration after injury. The purpose of our review is to describe the principles, status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration.

AB - Unlike heart valves or blood vessels, heart muscle has no replacement alternatives. The most challenging goal in the field of cardiovascular tissue engineering is the creation/ regeneration of an engineered heart muscle. Recent advances in methods of stem cell isolation, culture in bioreactors, and the synthesis of bioactive materials promise to create engineered cardiac tissue ex vivo. At the same time, new approaches are conceived that explore ways to induce tissue regeneration after injury. The purpose of our review is to describe the principles, status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration.

KW - Biomaterial

KW - Cell

KW - Heart

KW - Scaffold

KW - Tissue engineering

KW - Transplantation

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M3 - Review article

AN - SCOPUS:12844288101

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JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 2

ER -

Cells, scaffolds, and molecules for myocardial tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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