Cellular correlates of olfactory learning in the rat piriform cortex

E. Barkai, D. Saar

    Research output: Contribution to journalReview articlepeer-review

    54 Scopus citations

    Abstract

    This review describes research that combines cellular physiology with behavioral neuroscience, to study the cellular mechanisms underlying learning and memory in the mammalian brain. Rats were trained with an olfactory conditioning paradigm, in which they had to memorize odors in order to be rewarded with drinking water. Such training results in rule learning, which enables enhanced acquisition of odor memory. Training results in the following learning-related physiological modifications in intrinsic and synaptic properties in olfactory (piriform) cortex pyramidal neurons: 1. increased neuronal excitability, indicated by reduced afterhyperpolarization, and 2. increased synaptic transmission, indicated by reduced paired-pulse facilitation. These modifications are correlated to enhanced learning capability rather than to storage of memory for specific odors. In addition, using a different paradigm of odor-training, it is shown that NMDA and betra-adrenergic receptors are involved at different stages of long-term memory consolidation.

    Original languageEnglish
    Pages (from-to)111-120
    Number of pages10
    JournalReviews in the Neurosciences
    Volume12
    Issue number2
    DOIs
    StatePublished - 1 Jan 2001

    Keywords

    • Afterhyperpolarization
    • Olfactory learning
    • Paired pulse facilitation
    • Pirifom cortex
    • Pyramidal neurons

    ASJC Scopus subject areas

    • Neuroscience (all)

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