Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles

Ron Dagan; Moshe Phillip; Israel Sarov; Agneta Skibin; Sarah Epstein; Oded Kuperman

doi:10.1002/jmv.1890220209

Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles

Ron Dagan
, Moshe Phillip
, Israel Sarov
, Agneta Skibin
, Sarah Epstein
, Oded Kuperman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The changes occurring in the T‐cell subsets during acute symptomatic measles were examined in ten malnourished and 18 well nourished hospitalized children younger than 5 years of age (median age 14 months). A significant decrease in total lymphocyte count was observed. which was due mainly to a decrease in helper/inducer T lymphocytes, whereas the suppressor/cytotoxic T‐lymphocyte subset remained unchanged. Consequently, helpdsuppressor ratio decreased significantly during the acute phase of the disease. A reduced response to mitogens (PHA, Con A, PWM) was also observed. Malnourished infants showed a trend toward a deeper depression in both helper and suppressor T cells during the acute phase than well nourished children, whereas the helper/suppressor ratio remained similar in the two groups.

Original language	English
Pages (from-to)	175-182
Number of pages	8
Journal	Journal of Medical Virology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1002/jmv.1890220209
State	Published - 1 Jan 1987

Keywords

helper T lymphocytes
malnutrition
suppressor T lymphocytes

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.1890220209

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title = "Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles",

abstract = "The changes occurring in the T‐cell subsets during acute symptomatic measles were examined in ten malnourished and 18 well nourished hospitalized children younger than 5 years of age (median age 14 months). A significant decrease in total lymphocyte count was observed. which was due mainly to a decrease in helper/inducer T lymphocytes, whereas the suppressor/cytotoxic T‐lymphocyte subset remained unchanged. Consequently, helpdsuppressor ratio decreased significantly during the acute phase of the disease. A reduced response to mitogens (PHA, Con A, PWM) was also observed. Malnourished infants showed a trend toward a deeper depression in both helper and suppressor T cells during the acute phase than well nourished children, whereas the helper/suppressor ratio remained similar in the two groups.",

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AU - Phillip, Moshe

AU - Sarov, Israel

AU - Skibin, Agneta

AU - Epstein, Sarah

AU - Kuperman, Oded

PY - 1987/1/1

Y1 - 1987/1/1

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AB - The changes occurring in the T‐cell subsets during acute symptomatic measles were examined in ten malnourished and 18 well nourished hospitalized children younger than 5 years of age (median age 14 months). A significant decrease in total lymphocyte count was observed. which was due mainly to a decrease in helper/inducer T lymphocytes, whereas the suppressor/cytotoxic T‐lymphocyte subset remained unchanged. Consequently, helpdsuppressor ratio decreased significantly during the acute phase of the disease. A reduced response to mitogens (PHA, Con A, PWM) was also observed. Malnourished infants showed a trend toward a deeper depression in both helper and suppressor T cells during the acute phase than well nourished children, whereas the helper/suppressor ratio remained similar in the two groups.

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KW - suppressor T lymphocytes

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Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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