Cellular reconstitution of actively self-organizing systems

Orit Sitxon-Mendelson, Barak Gilboa, Yaron Ideses, Anne Bernheim-Groswasser

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Living cells are extremely sophisticated devices that detect specific environmental signals, process this information, and generate specific mechanical responses, such as growth, shape change, or directed movement. The active part of the biodevice is the cell cytoskeleton, a spatially extended network (gel), self-organized, mechanochemical machine that forms via the nucleation and multiscale self-organization of biomolecules (e.g., biopolymers such as filamentous actin [F-actin], microtubules [MTs], accessory proteins, and molecular motors [1,2]), in both the temporal and spatial domains. The cytoskeleton determines the mechanical properties of a cell and plays important roles in many cellular processes, such as division [3-5], motility [6], adhesion [7], and tissue morphogenesis. The multiscale nature of the cytoskeleton enables response times ranging from fast dynamics for individual molecular-sized building blocks to the persistent motion or shape change of whole cells over minutes and hours, well beyond the time range of man-made analogues.

Original languageEnglish
Title of host publicationCell and Matrix Mechanics
PublisherCRC Press
Pages63-100
Number of pages38
ISBN (Electronic)9781466553828
ISBN (Print)9781466553811
DOIs
StatePublished - 1 Jan 2014

ASJC Scopus subject areas

  • Medicine (all)
  • Biochemistry, Genetics and Molecular Biology (all)

Fingerprint

Dive into the research topics of 'Cellular reconstitution of actively self-organizing systems'. Together they form a unique fingerprint.

Cite this