Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

Hagai Yanai, Albert Shteinberg, Ziv Porat, Arie Budovsky, Alex Braiman, Rolf Zeische, Vadim E. Fraifeld

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with unknown etiology and no effective treatment. In this study, we show that primary cultures of fibroblasts derived from lung biopsies of IPF patients exhibited (i) accelerated replicative cellular senescence (CS); (ii) high resistance to oxidative-stress-induced cytotoxicity or CS; (iii) a CS-like morphology (even at the proliferative phase); and (iv) rapid accumulation of senescent cells expressing the myofibroblast marker α-SMA. Our findings suggest that CS could serve as a bridge connecting lung aging and its quite frequent outcome -- pulmonary fibrosis, and be an important player in the disease progression. Consequently, targeting senescent cells offers the potential of being a promising therapeutic approach.

Original languageEnglish
Pages (from-to)664-672
Number of pages9
JournalAging
Volume7
Issue number9
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Aging
  • Cellular senescence
  • Fibroblasts
  • Idiopathic pulmonary fibrosis
  • Myofibroblasts

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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