Ceramide metabolism and parkinson’s disease—therapeutic targets

Antía Custodia; Marta Aramburu-Núñez; Clara Correa-Paz; Adrián Posado-Fernández; Ana Gómez-Larrauri; José Castillo; Antonio Gómez-Muñoz; Tomás Sobrino; Alberto Ouro

doi:10.3390/biom11070945

Ceramide metabolism and parkinson’s disease—therapeutic targets

Antía Custodia, Marta Aramburu-Núñez, Clara Correa-Paz, Adrián Posado-Fernández, Ana Gómez-Larrauri, José Castillo, Antonio Gómez-Muñoz, Tomás Sobrino, Alberto Ouro

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells. Its metabolic dysfunction may lead to or be a consequence of an underlying disease. Recent reports on transcriptomics and electrospray ionization mass spectrometry analysis have demonstrated the variation of specific levels of sphingolipids and enzymes involved in their metabolism in different neurodegenerative diseases. In the present review, we highlight the most relevant discoveries related to ceramide and neurodegeneration, with a special focus on Parkinson’s disease.

Original language	English
Article number	945
Journal	Biomolecules
Volume	11
Issue number	7
DOIs	https://doi.org/10.3390/biom11070945
State	Published - 1 Jul 2021
Externally published	Yes

Keywords

Ceramide
Ceramide synthase
Neurodegeneration
Parkinson’s disease
Sphingolipidomics
Sphingolipids
Sphingomyelinase
β-GCase

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biom11070945

Cite this

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abstract = "Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells. Its metabolic dysfunction may lead to or be a consequence of an underlying disease. Recent reports on transcriptomics and electrospray ionization mass spectrometry analysis have demonstrated the variation of specific levels of sphingolipids and enzymes involved in their metabolism in different neurodegenerative diseases. In the present review, we highlight the most relevant discoveries related to ceramide and neurodegeneration, with a special focus on Parkinson{\textquoteright}s disease.",

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AU - Custodia, Antía

AU - Aramburu-Núñez, Marta

AU - Correa-Paz, Clara

AU - Posado-Fernández, Adrián

AU - Gómez-Larrauri, Ana

AU - Castillo, José

AU - Gómez-Muñoz, Antonio

AU - Sobrino, Tomás

AU - Ouro, Alberto

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells. Its metabolic dysfunction may lead to or be a consequence of an underlying disease. Recent reports on transcriptomics and electrospray ionization mass spectrometry analysis have demonstrated the variation of specific levels of sphingolipids and enzymes involved in their metabolism in different neurodegenerative diseases. In the present review, we highlight the most relevant discoveries related to ceramide and neurodegeneration, with a special focus on Parkinson’s disease.

AB - Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells. Its metabolic dysfunction may lead to or be a consequence of an underlying disease. Recent reports on transcriptomics and electrospray ionization mass spectrometry analysis have demonstrated the variation of specific levels of sphingolipids and enzymes involved in their metabolism in different neurodegenerative diseases. In the present review, we highlight the most relevant discoveries related to ceramide and neurodegeneration, with a special focus on Parkinson’s disease.

KW - Ceramide

KW - Ceramide synthase

KW - Neurodegeneration

KW - Parkinson’s disease

KW - Sphingolipidomics

KW - Sphingolipids

KW - Sphingomyelinase

KW - β-GCase

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U2 - 10.3390/biom11070945

DO - 10.3390/biom11070945

M3 - Review article

C2 - 34202192

AN - SCOPUS:85108426710

SN - 2218-273X

VL - 11

JO - Biomolecules

JF - Biomolecules

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M1 - 945

ER -

Ceramide metabolism and parkinson’s disease—therapeutic targets

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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